Chemotherapy was potentiated by E7449 and single agent had considerable antitumor action in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/β-catenin signaling in colon most cancers mobile lines, likely via TNKS inhibition. In step with this probability, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and appreciably altered expression of Wnt https://johne186vae9.wikiap.com/user