DNA ligases seal 5′-PO4 and 3′-OH polynucleotide finishes via 3 nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are necessary guardians of genomic integrity, and ligase dysfunction underlies human genetic ailment syndromes. Crystal constructions of DNA ligases bound to nucleotide and nucleic acid substrates have illuminated how https://sbobet63715.dreamyblogs.com/28416809/what-does-check-it-out-mean