High glucose links to dysfunctions of glucose uptake and catabolism and induces higher oxidative stress, dysfunction of endothelial cells. Higher hypertension results in cardiac and vascular injury. Central weight problems is relevant to maldistribution of free of charge fatty acid, overproduction of inflammatory molecules, and leptin resistance [21]. the editor(s) https://www.directivepublications.org/journal-of-cardiovascular-diseases/