One example is, abnormal activation of CaMKII is usually characterised by enhanced activity of Ca2+ channel gating, leakage of Ca2+ from sarcoplasmic reticulum, and dysregulation of Ca2+ homeostasis, which can jointly lead to arrhythmia and heart failure. Hashimoto et al. -indazole derivatives with disubstituent groups at both 4-situation and six-situation. https://caidengarhw.bloggazza.com/30669843/what-does-indazole-3-carboxamide-mean